Direct application of plasmid DNA containing type I interferon transgenes to vaginal mucosa inhibits HSV-2 mediated mortality

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Author: Austin, BA
Author: Carr, DJ
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Methods Article

Direct application of plasmid DNA containing type I interferon transgenes to vaginal mucosa inhibits HSV-2 mediated mortality

Bobbie Ann Austin¹, Cassandra M. James², Peter Härle³ and Daniel J.J. Carr⁴^*

¹ Department of Ophthalmology, University of Oklahoma Health Sciences Center. Oklahoma City, OK. USA.
² Division of Veterinary & Biomedical Health Science, Murdoch University. Perth. Australia 6150.
³ Laboratory of Neuroendocrinoimmunology, University Medical Center. Regensburg. Germany 93053.
⁴ Departments of Ophthalmology and Microbiology and Immunology, University of Oklahoma Health Sciences Center. Oklahoma City, OK. USA.

* To whom correspondence should be addressed: Daniel J.J. Carr, Departments of Ophthalmology and Microbiology and Immunology, University of Oklahoma Health Sciences Center. Oklahoma City, OK. USA. Email: dan-carr@ouhsc.edu

Biol. Proced. Online 2006;8:55-62. doi:10.1251/bpo118
Submitted: November 14, 2005; Accepted: May 17, 2006; Published: June 14, 2006.

Indexing terms: Virus; Interferon; T-lymphocyte; Transgene.

Figure 1 Enlarged

Fig. 1:

A comparison of cumulative survival of mice when treated with IFN-α1, -α5, and –β transgenes and with vector alone.

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